Matrine, Plant Extract Alkaloid, Radix Sophorae Flavescentis manufacturer / supplier in China, offering GMP, Matrine, Anticarcinogen, Antivirus, Pure Herbal Medicine, 100%Natural Medicine, Top Wine, EU Organice Raspberry Wine Brut /Sweet Rich SOD Anthocyanin, Amino Acids, Anticancer, Antiaging, Blood Tonic, Prevention Ischemic Strok, Emodin and so on.
|Min. Order:||25 kg|
|Payment Terms:||L/C, T/T|
|Anticarcinogen, Antivirus, Pure Herbal M:||Plant Extract, 100%Natural Medicine|
|Raw Material:||Anticarcinogen, Antivirus, Pure Herbal Medicine|
|The lightyellow sophora root pharmacological effects:|
|1.The antitumor effect|
Matrine has anti-cancer activity, the mice celiac injection of 500 μ g.d group 2 mo survival rate was 40%, and the control group in 23 days all died. The oxymatrine has no effect to this. Matrine in vitro with lower the mice abdominal macrophage P815 inhibition of tumor cell proliferation effect. The Sophocarpine also have anti-cancer activity, in experimental mice to S-180, U-14. ECA, L and tumor strains are performance obvious inhibition. Matrine, oxymatrine, locust fruit base and different proportion of mixed A and B, C base on S-180 solid tumor all have different degrees of inhibition, each monomer alkaloids are the anti-tumor rate in more than 35%, the different proportion of mixed C alkali dosage in 113 mg/kg-d), continuous celiac injection drug 10 days anti-tumor rate is 61.38%, increased by 23.5% than the total alkali, and compared with simple matrine, there is significant difference (P<0.01). Matrine on chronic myeloid leukemia peripheral multidirectional hematopoietic progenitor cells colony generation rate has significant inhibitory action, the inhibition rate is 0.76, the best inhibition concentration is 100 mg/L. Bitter and water solution effect in vitro culture of people early young grain of leukemia cells, when the dose is 8 mg/ml, can pronouncedly induced leukemia cell to mononuclear macrophage direction differentiation.
|2.Rising leucocyte effect|
Oxymatrine can prevent mice caused by MMC, cyclophosphamide for leucopenia, intravenous or intramuscular injection 30 mg/kg total matrines and 100 mg/kg oxymatrine to normal peripheral blood leukocyte count were significantly elevated effect, and oxymatrine rise to normal rabbit white effect markedly effective time, maintain time and white blood cell count peak and total matrines compared, during the 18 days after give medicine the basic is consistent, rise white effect is better than that of shark liver alcohol. In the total matrines, oxymatrine, matrine of rabbit X line 600 G y exposure caused by the treatment of leucopenia experiments, total matrines group to medicine from 5 days to the first l9 days, the white blood cell count basic remain at 6000 / mm 3 above, and control group until 22 days recover the above level; Oxymatrine rise white valence is not higher than total alkali, matrine, did not see the treatment effect. Oxymatrine for rabbit after 60 cobalt r-ray 500 Aaron whole body irradiation caused by leucopenia, dose rate is 31 G y/min, display a certain control role, in dose rate of 120 G y/min no prevention and cure function.
|3.For the cardiovascular system effect|
1/4 LD50 of matrine and oxymatrine intravenous significant against aconitine and chloroform epinephrine induced rat cardiac arrhythmia, Celiac injection significantly mice against chloroform induced ventricular fibrillation, also improve aconitine induced rat cardiac arrhythmia the dosage, against barium chloride induced rat cardiac arrhythmia and ligation rat in the anterior descending coronary induced arrhythmia. To rabbit intravenous 30 mg/kg oxymatrine, shorten the adrenaline induced arrhythmia recovery time, treatment to medicine average shorten 43%, prevent giving medicine average shorten 22%. Intravenous 42 mg/kg sophocarpine can be against the calcium chloride induced mice ventricular arrhythmia and aconitine induced rat cardiac arrhythmia, Intravenous l6mg/kg can improve ouabain cause rabbit premature beat and cardiac arrest required dosage, can also fight coronary blocking, then perfusion induced arrhythmia, but not against the calcium chloride-acetylcholine in mice induced atrial fibrillation (snap) and chloroform epinephrine induce rabbit arrhythmia.
|4.Relieving asthma expectoranting effect|
Matrine is mainly through the excited β receptor, especially is the β receptor in the excited central, removing bronchospasm and inhibition antibody and slow reaction material release and produce relieving asthma effect. Matrine in the calcium and the non calcium gram nutritional solution, all can defend the acetylcholine barium chloride excited in vitro guinea pig, rat trachea and intestinal canal effect. Total Matrines, oxymatrine of histamine induced asthma guinea pigs of relieving asthma effect and aminophylline basic issue issue is similar, one hour and relieving asthma rate in more than 90%, and the control group in about 15%, Flat out of time, aminophylline in six hours relieving asthma rate is 55%, total matrines is in more than 80%. sophocarpine Ach cause of asthma effect is stronger than aminophylline, its flat out of action may be through the excited mesencephalic beta receptors and action. Phenol red shedding method prove that, mice gavage total matrines, yellow ketone is 0.8 g/kg, have obvious eliminating phlegm effect.
|5.The stable effect|
The total matrines of 50-100 mg/kg can obviously inhibit the free movement of mice; 400 mg/kg of mice passive activities significantly inhibited; 100-200 mg/kg can restrain lonely mice's bucket attack behavior, total matrines of 25-40 mg/kg and hibernate spirit (5 mg/kg) share, can cause mice turn positive areflexia, 100-200 mg/kg total matrines can obviously strengthen 0.5 mg/kg reserpine in mice spontaneous activity inhibition; Bitter and total base 50-200 mg/kg and intraperitoneal injection of subthreshold dose of sodium pentobarbital 20-25 mg/kg share, can cause mice to sleep; Respectively with the thiopental (celiac injection, 40 mg/kg), chloral hydrate (celiac injection, 200 mg/kg) share, can significantly enhance its central inhibition. Also can obviously against central stimulant benzedrine (celiac injection, 4-6 mg/kg) and caffeine (50 mg/kg) of psychomotor excitement; total matrines for strychnine and amyl four nitrogen of convulsion not only no against effect, on the contrary make the convulsion enhancement and increase its animal deaths; total matrines used alone have mild analgesic effect, and threshold dose of morphine share, can significantly increase the analgesia percentage.
|6.The antiallergic effect|
Matrine can reduce allergic media release, is the immune inhibitors, the inhibition of 50% T cell proliferation concentration is 0.55-0.56 mg/ml; Inhibition IL-2 production concentration is 0.1 mg/kg.
|7.The immunity inhibition effect |
Matrine and oxymatrine in 1/5 LD50 doses on immune function in mouse also have an inhibitory effect. Rabbit and rat muscle injection oxymatrine 150 mg/kg or 100 mg/kg to passive or active skin allergic reaction all had significant inhibitory action, and to the rabbit serum IgE antibody formation had significant inhibitory action. Celiac injection of oxymatrine 200 mg/kg d., total 21 days, on mice speed hairstyle allergy causes death has protective effect.
Intramuscular injection oxymatrine can obviously against croton oil, carrageenin (rat) and glacial acetic acid (mouse) induced exudative inflammation. Rabbit lavage, subcutaneous injection, intravenous injection, celiac injection and intramuscular injection lightyellow sophora root decoction, radix sophorae flavescentis injection and matrine were diuretic effect, urine sodium chloride content has significantly increased. Radix sophorae flavescentis 50% methanol extract has good hydrochloric acid by ethanol of ulcer effect, the active components is kurarinone. In addition, matrine in vivo and vitro have antibacterial effect, body strength and chloramphenicol quite, alcohol extract in vitro have resistance to trichomonad function, its strength close to the hops.