Product name: Resveratrol
Plant source: Polygonum cuspidatum/Polygonaceae plants of giant knotweed root drying
Molecular formula: C14H12O3
Molecular weight: 228.24
CAS no. : 501-36-0
Content: 10% , ≥ 20%, 50%, 80%, 98%, 99%
Appearance: Low content of color: Brown or dark brown;High content of color light yellow or white powder
Detection method: HPLC
Specification: 25 KG/barrel (Inner: Vacuum packing)
Resveratrol is a polyphenol compounds, mainly derived from grape (Red wine), giant knotweed, peanut, mulberry and other plants.Resveratrol is a kind of biological strong natural polyphenols, also known as the three phenol stilbene, is cancer chemoprevention agents, is also to reduce platelet aggregation, the prevention and treatment of atherosclerosis, disease of heart head blood-vessel chemoprophylaxis agent.The United States department of agriculture research results show that the Peanuts red skin and peanut kernel also contains a considerable amount of resveratrol. The resveratrol, experimental studies have confirmed that have beneficial effects on cardiovascular disease and cancer.
Product function: It has as the oxidation resistance, can decrease the blood viscosity, inhibit platelet coagulation and vasodilation, keep the blood flowing, can prevent the occurrence of cancer and development of resistance to atherosclerosis and coronary heart disease, ischemic heart disease, hyperlipidemia prevention role.The role of inhibiting tumor also have estrogen-like effect, can be used to treat diseases such as breast cancer
Pharmacological effects: Antibacterial, antiviral, anti-tumor, anti-hepatitis, platelet aggregation suppression and thromboxane B2 generation. It can prevent low-density lipoprotein oxidation, cardiovascular diseases and cancer, resist virus and adjust immunity. Its main function is its antioxidant properties.
Product function: It has the oxidation resistance, can decrease the blood viscosity, inhibit platelet coagulation and vasodilation, keep the blood flowing, can prevent the occurrence of cancer and development of resistance to atherosclerosis and coronary heart disease, ischemic heart disease, hyperlipidemia prevention role.The role of inhibiting tumor also have estrogen-like effect, can be used to treat diseases such as breast cancer
(1), In turn, can reduce blood lipids and the incidence of coronary heart disease of cardiovascular system with special protection;
(2) To adjust the proportion of low density lipoprotein (LDL);
(3) Reduce platelet aggregation, and so on;
(4) The anti-aging;
(5) Prevent cancer is expected to become a kind of natural medicine.
Its molecular structure, mechanism of action is clear, is a typical one of the third generation of health food raw materials;Its effect is clear, is a kind of important natural drugs raw material;The anti-oxidation, anti-aging, the hairdressing cosmetic industry is the important raw material products.Over the past 2007 years, Europe and the United States has developed into a health food, dosage form has a tablet, capsule, oral liquid.
In December 2013, from the transformation of neuroscience center at the university of Missouri, professor Dennis found that resveratrol not only exists in grapes and giant knotweed, also widely exists in a variety of fruits and vegetables.Meters unveiled his music professor and a group of a recent study on resveratrol, a natural source of resveratrol component can be significantly reduced because long-term neurological drugs methamphetamine addicts.
Because of resveratrol has many biological and pharmacological activities, make it widely used in food, medicine, health care products, cosmetics, etc.Resveratrol has good pharmacological activity and health care function The market demand is very big and swell, for most of the countries and regions have developed resveratrol and its products.Has the resveratrol as a dietary supplement in the United States, Japan has been extracted from plants of resveratrol as a food additive, China has made JiangZhiMei will contain resveratrol, plant extracts of natural health food.
To prevent food allergies:
Some body immune mechanism to eggs, wheat and milk and other food produce allergic reaction, severe cases can lead to shock and even death.Japanese researchers found in animal experiments, rich content of resveratrol in red wine can prevent this kind of food allergies.
React with other drugs:
May be the side effects of resveratrol, the largest blood dilution, this could give people who are taking other drugs.Therefore, understanding whether resveratrol interactions with other drugs is very important.In addition, the combination of resveratrol and other vitamin inappropriate application will have a negative impact.
About the safety of high dose intake resveratrol and side effects reported is have no. Since the resveratrol on play its function is so effective, and so its dosage is low.Within the scope of the normal dose not any noticeable adverse effects have been reported.
Resveratrol soft capsule
Resveratrol does to function of the human body:
Shen etc also contain the components in the plant.Natural white hellebore alcohol is a kind of natural active ingredients, it can be to free (cis and trans) and glycosidic combination state (Cis-From and trans) two forms in the plant (such as traditional Chinese medicine (TCM) giant knotweed) distribution, biosynthesis, and all with antioxidant effectiveness, including biological activity than cis trans isomer, is a kind of important phytoalexin in grapes.People carried out extensive research on its natural resources, at least in 21, 31 genera, 72 species of resveratrol were found in plants, such as: the grapes, the grapes of genera, also belong to the snake Portugal, leguminous groundnuts, tree, robinia genus, hellebore genus of liliaceae, myrtle division of eucalyptus, polygonaceae fagopyrum esculentum, etc.Many plants contain resveratrol is common medicinal plants, such as tree, hellebore, giant knotweed, there is food, such as: the grapes.The highest content of resveratrol in grape skin, 50 ~ 100 g /.
In 1992 for the first time found that resveratrol in commercial wine. Abroad, numerous studies have demonstrated that resveratrol is a wine, particularly red wine in the effect of the most important ingredient. However, not all have this ingredient in red wine, blending wine and inferior wine can not test out resveratrol. Because the resveratrol is under ultraviolet light, a phytoalexin produced by the grape.If it will work in the wine brewed method the influence of the reed alcohol content is significant.Resveratrol in grape material exist in cis structure, although the content of resveratrol in grape raw material is lower, but the use of advanced brewing technology can make the grapes resveratrol glucoside in glucose under the action of glucosidase, J} into trans white hellebore alcohol, so that the content of resveratrol in grape wine increased sharply.Trans resveratrol is generally recognized as the red wine can fight sclerosis of arterial congee appearance and the important component of coronary heart disease.Therefore, the discretion of the content of resveratrol in grape wine has become the important indicators of quality wine or inferior wine.
In the 1980 s, the world health organization survey found that although the French prefer cheese high fat food, but the incidence of coronary heart disease and mortality rate is lower than other western countries, the reason may be that related to the French people often drink vinous wine contains resveratrol.
Resveratrol is a kind of natural antioxidants that may reduce the blood viscosity, inhibit platelet coagulation and vasodilation, keep the blood flowing, can prevent the occurrence of cancer and development of resistance to atherosclerosis and coronary heart disease, ischemic heart disease, hyperlipidemia prevention role.The role of inhibiting tumor also have estrogen-like effect, can be used to treat diseases such as breast cancer.
In the 1990 s, China's science and technology workers of resveratrol studies have advanced, and reveal its pharmacological effects: inhibit platelet condensed with regard to the prevention of myocardial forcedly, cerebral embolism, of anoxic cardiac protection, a control and weight loss effect to the fat person can, to burn or uncontrolled hemorrhagic shock caused by cardiac output fell by effective recovery, and can expand arteries and improve microcirculation.At the same time our country biological technology co., LTD. The research of resveratrol extraction and industrialized production, have now begun to take shape.
Eat peanut products, can alleviate the cardiovascular disease, reduce blood fat, anti-aging.Resveratrol health food will become the new fashion for nutrition and health in the 21st century.
Fever and pain:
Resveratrol, through a variety of different ways to play therapy efficacy, antipyretic and analgesic activity.In mice and rats a complete body of research shows that resveratrol can not affect blood pressure under the condition of given gastric mucosa resistance caused by gastric secretion suppressed the excitability of dyke sores.
Anti-cancer, anti mutation function:
In 1993, Jayafilake etc. Research has shown that trans resveratrol and have antitumor activity, the reason is that they can inhibit the activity of protein tyrosine kinase.Jang team further pointed out, such as resveratrol in the three stages of cancer initiation, improve and development process, has a larger anti-cancer activity, and cancer function to inhibit or even reverse the three phases:
First, the inhibitory effect of starting.To reduce free radical formation, phase induction II medicine generation enzyme increased, antagonism dioxin role;
Second, the inhibitory effect of increase.Inhibition of an enzyme called cyclooxygenase (COX), inhibition of catalase.
Third, the inhibitory effect of development.Inhibit cancer cell proliferation, inducing cancer cell differentiation, inducing cancer cell apoptosis.Resveratrol is as protein tyrosine kinase inhibitors of PTK, many medical studies have found that resveratrol in breast cancer, stomach cancer, colon cancer, prostate cancer, leukemia, ovarian cancer, skin cancer and other malignant tumor cell has obvious inhibitory effect.
In January 1997, the United States at the university of Chicago, Illinois college of pharmacy, John Pezzuto the research team led by professor in the United States in the journal science, published titled "the grapes of natural products, antitumor activity of resveratrol, paper, cause sensation of medical science.Papers to prove that resveratrol can effectively inhibit cell activity associated with cancer in each process.As an antioxidant, mutant resistant agent and anti-inflammatory agent, resveratrol shows for cancer chemoprevention ability, can prevent cancer cells and stop the spread of the malignant tumor, chromic acid can inhibit protein kinase, by preventing kinase function and plays a role of resistance mutations, also inhibits inflammation cells.
Resveratrol also inhibits inflammation cells.The cell inflammation associated with closed section inflammation and other diseases.Resveratrol also inhibit protein tyrosine kinase a catalytic tyrosine phosphorylation of the material.The kinase is included in the regulation of cell mitosis in the cytoplasm of information transmission.Use of resveratrol inhibits protein tyrosine kinase, may be too stop kinase function and plays a role of resistance mutations.
Among the people, already use of traditional Chinese medicines contain resveratrol, giant knotweed treatment and prevention of hyperlipidemia and atherosclerosis.The study says.Resveratrol is mainly from the following several aspects play to prevention and cure of atherosclerosis, coronary heart disease Resistance and the cardiovascular protection:
1, Regulating blood lipid;2, inhibit platelet aggregation and promoting fibrinolysis, resisting thrombosis;3, protecting vascular endothelium, inhibit endothelial cell proliferation;4, protect vascular smooth cells, inhibit the proliferation;5, white blood cells;6, low density lipoprotein oxidation resistance function.Studies, the platelet activation induced by toxins or clotting enzyme found in the experiment, with resveratrol washing platelet after hatching, lipopolysaccharide in physiological plasma concentrations alone or lipopolysaccharide and blood coagulation enzyme activation of platelets to collagen adhesion block.With resveratrol pretreatment blood platelet fibrinogen have also been block.Resveratrol and its derivatives is a kind of phytoalexin more research in recent years, its cardiovascular protective function gradually become a research hotspot, hopefully in drug development of prevention and treatment of cardiovascular disease, but its mechanism is far from clear, remains to be further in-depth study.
Prevent heart and liver injury:
Resveratrol inhibits the mice liver triglyceride and cholesterol deposition.It also can inhibit mice liver fat peroxide reaction and prompted aspartate aminotransferase and propylamine acid transaminase level rise.By analyzing the two kinds of enzymes in serum, heart and liver is a good diagnostic information can be obtained.
The antithrombotic function:
Resveratrol inhibits synthesis of lipoxygenase, this enzyme found in white cells, heart, brain, lung and spleen.Therefore, resveratrol can prevent the formation of blood clots in blood vessels.And in the use of clonidine after this fight high blood pressure medication, it also inhibits platelet aggregation.
Promote the immune system activity for wound treatment:
Resveratrol by strengthening the immune system and can also promote burn us.Someone resveratrol in restoring scald in mice was studied by the inhibition of cellular and humoral and nonspecific immune efficacy, controlled use of resveratrol provides a drug depend on the type of immune regulation.With different degree of severe burns study in mice shows that resveratrol can restore the damaged function, such as a response to antigen signal, hyperplasia and interleukins II synthesis and by lymphocyte antibody synthesis ability.Animals badly burned in the use of controlled resveratrol treatment, its level of neutrophil and adhesion rate of return to near normal levels, and prolong survival time.
Antioxidant, anti-free radical action:
Resveratrol is found in the natural antioxidant, mainly by eliminating or inhibit free radicals, inhibit lipid peroxidation and antioxidant enzyme activity related adjustment mechanisms play a role of antioxidant.Many hydroxyl stilbene class usually have antioxidant, anti-free radical effect.When the resveratrol in 1.3 mu g/mLtime, can obviously inhibit rat red blood cells from oxidative hemolysis and hemolysis induced by H2O2 oxidation, on heart, liver, brain, kidney of mice of lipid peroxide in vivo and in vitro has obvious inhibitory effect.Resveratrol oxidation, in addition to the lure of free radicals and the effect of arachidonic acid metabolism pharmacological function has attracted widespread interest, because the physiological metabolism involves many physiological disease is closely related to human health, such as atherosclerosis, alzheimer's disease, viral hepatitis, stomach ulcers, inflammation and allergic reaction, etc.
Anti-inflammatory, antibacterial effect:
Resveratrol on staphylococcus aureus, catarrh aureus, escherichia coli, pseudomonas aeruginosa has inhibitory effect, and the orphan virus, herpes simplex virus and intestinal virus, coxsackie A and B groups have A stronger inhibitory effect.Resveratrol by reducing platelet adhesion, in the process of anti-inflammatory activity in platelet achieve anti-inflammatory.
A team of scientists from the Italian pizza research found that resveratrol in grape can help fish prolong life.Accept the experiment of more than 100 fish, 30 of them were fed every day a small amount of resveratrol, 60 were fed right amount, 20 were fed with large component, the results of group 1 fish didn't see what effect, group 2 fish extended life by 27%, the third group of fish extended life by 50%.This is the first time scientists have found that white hellebore alcohol in vertebrates have prolong life.
Because resveratrol has anti-cancer, anti-oxidation, anti-inflammatory and antibacterial effect and love to the love of people, plant sources because said the French people often drink high fat content contains resveratrol, so the Frenchman's incidence of coronary heart disease in other western countries, what do we learn from the information in the resveratrol because effectively suppress high fat prevention role.
While many people know that resveratrol is to suppress the effect of fat, but in our country has not been widely used in weight loss products, resveratrol can not only have anti-cancer, anti-oxidation, anti-inflammatory, antibacterial effect, and the effect of weight loss, so the resveratrol became a new research group weight loss products to lose weight, to extract resveratrol technology not only can smooth wheezing phlegm, inhibit bacteria, treatment of abdominal pain, diarrhea, clearing away heat and toxic materials, spleen and stomach, can thoroughly eliminate the effect of fat.But is for the king of the king of health care.
Because of resveratrol has many biological and pharmacological activities, make it widely used in food, medicine, health care products, cosmetics, etc.Resveratrol has good pharmacological activities and health care function of its market demand is very big and swell, there are most of the countries and regions have developed resveratrol and its products.Has the resveratrol as a dietary supplement in the United States, Japan has been extracted from plants of resveratrol as a food additive in China has made from plant extracts containing resveratrol JiangZhiMei capacity of natural health food.