Product description: The mushroom is one of the most common delicious food, and it is also the one of most types of species, some mushroom looks very bright but contains highly toxic is not able to use, some mushroom looks very strange, but it is delicious nutrition food.
Amanita(or called Amanita muscaria )---The world's most famous mushroom
In popular culture, the amanita is the most easy to be identified which is also the most common. They often appear in the children's books, movies, decorations, greeting cards and computer games. In the classic card game "Super Mary, " you will not surprised to find their figure. It also has often been called fly bacteria, because in the well-known German philosopher big Albert's work had said: "it is called Amanita muscaria, because put it in the milk it can kill the flies. "
Amanita---Origin and species Amanita muscaria is a kind of can be used for neural virulent fungus, it has several subspecies, which present yellow, brown, pink, etc. The Amanita bright color makes them easy to be identified in Europe, this kind of plant's flowers from pale green to olive yellow all kinds of color, in the United States east coast also can see its figure. But in the United States, this kind of plant has from white to light brown and so on the different color.
Digest the correlation: Tumor translational medicine » Nature: Poisonous mushrooms don't "poison", to help fight cancer
On April 27, 2015 - / - sometimes cancer researchers consider from death cap "poisonous mushroom derived the toxicity of alpha goose cream mushroom alkali as a potential cancer therapy drugs, however, due to the alpha goose cream mushroom base will cause the possibility of liver toxicity, so is often considered as an effective therapy has a lot of restrictions. Recently published an article in the international research papers on the journal Nature, researchers from the university of Texas MD cancer research center focused on developing a alpha goose cream mushroom alkali based antibody drug conjugate (ADCs), they can find ADCs POLR2A genes as targets to effective treatment have the mouse model of colorectal cancer, the drug could effectively promote tumor regression and dramatically reduce their toxicity, targeting the function of ADCs also will improve the cancer cell, as much as possible to reduce the impact on the healthy cells.
Xiongbin professor Lu said, when the traditional TP53 tumor suppressor genes knocked out after will cause cancer development, and its nearby genes POLR2A will be removed at the same time;Normal cells have two copies POLR2A and TP53 genes, and in this paper, we study researchers to contain a single copy two genes of cancer cells, a single copy of the two genes in 53% of colorectal cancer, 62% of breast cancer, and 75% of ovarian cancer.
POLR2A is a kind of cells, including cancer cells to survive must genes, because its only a single copy, so that the cancer cells can unusually sensitive to inhibition of the gene.As POLR2A and TP53 genes are eliminated at the same time means that targets the two genetic therapy become less effective in the process of making the cancer cells continue to grow well;And reveals a single copy of POLR2A gene may can promote the development of cancer and help scientists find new targets for cancer treatment;The role of article, the researchers tested the ADCs, found that it can effectively restrain POLR2A gene expression, thereby inhibiting the development of cancer.
In cancer therapy, the researchers spent great efforts to try to restore the activity of TP53, because of the complexity of the TP53 signals, however, there is no TP53 based therapy successfully transformed into the clinical stage of cancer therapies.POLR2A gene can encode an enzyme, the enzyme will be alpha goose cream mushroom base only so, the researchers found that a low dose of alpha goose cream of mushroom alkali genes POLR2A can inhibit cancer cell growth, and reduce the toxicity.